Phase 1 ¹ First-In-Human study designed to assess safety   ,   tolerability   , right dose for Phase 2 and early signs of efficacy   of 177Lu-RAD20   2   in individuals with   advanced HER2-positive solid   tumors

Previous clinical proof-of concept data ² for targeting HER-2 demonstrated the safety and biodistribution of 99mTc-RAD202 in humans

Radiopharm Theranostics (ASX:RAD, ‘Radiopharm’ or the ‘Company’), a clinical-stage biopharmaceutical company focused on developing innovative oncology radiopharmaceuticals for areas of high unmet medical need, today announced the dosing of the first patient in its Phase 1 ‘HEAT’ clinical trial of RAD202, a proprietary nanobody that targets Human Epidermal Growth Factor Receptor 2 (HER2)-positive expression in a wide array of advanced solid tumors.

The open-label Phase 1 ‘HEAT’ clinical trial is a dose escalation trial of 177Lu-RAD202 that is designed to determine the recommended Phase 2 dose and to evaluate the safety and preliminary clinical activity of this novel radiotherapeutic in individuals with HER2-expressing advanced cancers. The study is currently being conducted at clinical centers across Australia.

‘Dosing patients in the HEAT clinical trial marks an important milestone in our transition to a clinical-stage company,’ said Riccardo Canevari, CEO and Managing Director of Radiopharm Theranostics. ‘Despite progressive improvements in the management of metastatic HER2-positive disease, the majority of patients experience disease progression on current standard of care and require further therapeutic options. The dosing of the first patient in the ‘HEAT’ trial represents a significant step toward achieving RAD202’s potential to address an unmet need for HER2-positive metastatic patients who are progressing or unable to tolerate current treatment options. With RAD202, we hope to provide an option that can meaningfully improve clinical outcomes for HER2-positive patients, while preserving their quality of life.’

HER2 is overexpressed in breast cancer as well as several other solid tumors and represents a validated target in oncology. RAD202 is a proprietary single domain antibody that targets HER2. Ten HER2-positive breast cancer patients previously dosed in a Phase 1 diagnostic study of RAD202 demonstrated clinical proof-of concept as well as the safety and biodistribution of RAD202, validating its potential for the treatment of advanced HER2-expressing cancers ² . Preclinical findings ³ examining the therapeutic effect in HER2-positive xenografts were also recently reported with 177Lu-RAD202. Collectively, these data further justify first in humans dose finding studies.

‘It is a privilege to be the first centre to administer 177Lu-RAD202, targeting HER2-positive tumors in this Phase 1 clinical trial (HEAT).’ said Dr Aviral Singh, Clinical Head of Theranostics and Nuclear Medicine at St John of God Murdoch Hospital. ‘This opens the possibility of novel therapeutic avenues for patients with aggressive tumor types, including breast, ovarian, gastric, pancreatic, bladder, and several other cancers. With the trust put in us by Radiopharm, we look forward to a successful trial with beneficial outcomes for our patients.’

About Radiopharm Theranostics

Radiopharm Theranostics is a clinical stage radiotherapeutics company developing a world-class platform of innovative radiopharmaceutical products for diagnostic and therapeutic applications in areas of high unmet medical need. Radiopharm is listed on ASX (RAD) and on NASDAQ (RADX). The company has a pipeline of distinct and highly differentiated platform technologies spanning peptides, small molecules and monoclonal antibodies for use in cancer. The clinical program includes one Phase 2 and three Phase 1 trials in a variety of solid tumor cancers including lung, breast, and brain metastases. Learn more at radiopharmtheranostics.com .

Authorised on behalf of the Radiopharm Theranostics board of directors by Chairman Paul Hopper.

For more information:
Riccardo Canevari
CEO & Managing Director
P: +1 862 309 0293
E: rc@radiopharmtheranostics.com

Anne Marie Fields
Precision AQ (Formerly Stern IR)
E: annemarie.fields@precisionaq.com

Paul Hopper
Executive Chairman
P: +61 406 671 515
E: paulhopper@lifescienceportfolio.com

Media
Matt Wright
NWR Communications
P: +61 451 896 420
E: matt@nwrcommunications.com.au

________________________________

¹ clinicaltrials.gov/study/NCT06824155
² Zhao et al, Molecular Pharmaceutics 2021 18 (9), 3616-3622
³ Altunay B. et al, EP-0136, Eur J Nucl Med Mol Imaging (2024) 51 (Suppl 1): S1–S1026. DOI: 10.1007/s00259-024-06838-z

(TheNewswire)

Un groupe financier privé mondial dont le siège social est à San Francisco conseille sur la facilité de construction pour soutenir l’expansion des usines modulaires d’hydrogène vert de Charbone en Amérique du Nord.

Brossard (Québec) TheNewswire – le 4 juin 2025 – CORPORATION CHARBONE HYDROGÈNE (TSXV: CH OTCQB: CHHYF, FSE: K47 ) (« Charbone » ou la « Société »), une rare compagnie cotée en bourse spécialisée dans la production et la distribution d’hydrogène vert en Amérique du Nord, est heureuse d’annoncer plus de détails sur la signature, annoncée le 1 er mai 2025, d’un financement de projets d’un montant maximal de 50 millions de dollars américains, accordé par un fonds privé géré par True Green Capital Management LLC (« TGC »). US Capital Global Securities LLC, la division de courtage enregistrée auprès de la SEC du groupe financier privé mondial US Capital Global, a agi en tant que conseiller principal et facilitateur.

Basée à Montréal, Charbone développe des usines de production modulaires ciblant l’hydrogène d’une pureté de 99,999 % (grade 5.0 et supérieur), avec toute la production pré-vendue via des contrats de ventes à des clients de premier niveau.

‘ Nous sommes fiers d’avoir servi de conseiller principal à la fois à Charbone et à TGC sur cette transaction , a dit Charles Towle, Chef de la direction à US Capital Global Securities. ‘ Charbone connaît une forte dynamique, face à la demande croissante de solutions d’hydrogène propre pour décarboner les utilisateurs industriels grâce à ses principaux sites en développement en Amérique du Nord. Nous sommes impatients de soutenir la croissance continue de l’entreprise. La transaction a été menée par Lisa Terk, vice-présidente principale et banquière de premier plan spécialisée dans les technologies propres et les énergies renouvelables à notre siège mondial . ‘

‘ Ce financement marque une étape importante dans l’exécution de notre stratégie de croissance à long terme , a dit Benoit Veilleux, Chef de la direction financière de Charbone. ‘ Nous sommes reconnaissants à US Capital Global pour son soutien constant et son expertise tout au long de ce processus, depuis la structuration et de l’engagement des investisseurs jusqu’à la réussite de la documentation juridique . ‘

Hervé Touati, Directeur Général à TGC, a ajouté : ‘ Nous sommes heureux de financer Charbone et nous réjouissons de collaborer à cette initiative conjointe en matière d’énergie propre et renouvelable. Nous apprécions la diligence et la perspicacité de US Capital Global qui ont permis à cette opportunité d’aboutir . ‘

À propos de Charbone Hydrogène Corporation

Charbone est une entreprise intégrée d’hydrogène vert disposant de capacités stratégiques de distribution de gaz industriels en Amérique du Nord. Tout en poursuivant le développement de son réseau modulaire de production d’hydrogène vert, Charbone s’appuie également sur des partenariats commerciaux pour fournir de l’hydrogène, de l’hélium et d’autres gaz industriels sans les exigences en capital élevées des usines de production. Cette approche améliore les sources de revenus, réduit les risques opérationnels et accroît la flexibilité sur le marché. Charbone reste la seule société purement axée sur l’hydrogène vert cotée en bourse en Amérique du Nord, avec des actions cotées à la Bourse de croissance TSX (TSXV: CH); sur les marchés OTC (OTCQB: CHHYF); et à la Bourse de Francfort (FSE: K47). Pour plus d’informations, visiter www.charbone.com .

À propos de True Green Capital

True Green Capital Management LLC (« TGC ») est un gestionnaire de fonds spécialisé dans les infrastructures d’énergies renouvelables, spécialisé dans la production d’électricité décentralisée aux États-Unis et en Europe. Depuis 2011, TGC finance et gère des actifs d’énergie propre générant des rendements stables et faiblement corrélés. Basé à Westport, dans le Connecticut, TGC dispose également d’un bureau à Londres. Pour en savoir plus, rendez-vous sur www.truegreencapital.com .

À propos de US Capital Global

Fondée en 1998, US Capital Global propose une gamme de solutions financières avancées, comprenant des produits de dette, de capitaux propres et d’investissement personnalisés pour les entreprises et les investisseurs du marché intermédiaire. La société supervise des fonds d’investissement directs et propose des services complets de gestion de patrimoine et de banque d’investissement, incluant des stratégies de fusions-acquisitions et une expertise en levée de capitaux. Parmi les entités notables du consortium figurent US Capital Global Investment Management LLC, US Capital Global Wealth Management LLC et US Capital Global Securities LLC, courtier-négociant enregistré auprès de la SEC et membre de la FINRA. Pour en savoir plus, visiter www.uscapital.com .

Énoncés prospectifs

Le présent communiqué de presse contient des énoncés qui constituent de « l’information prospective » au sens des lois canadiennes sur les valeurs mobilières (« déclarations prospectives »). Ces déclarations prospectives sont souvent identifiées par des mots tels que « a l’intention », « anticipe », « s’attend à », « croit », « planifie », « probable », ou des mots similaires. Les déclarations prospectives reflètent les attentes, estimations ou projections respectives de la direction de Charbone concernant les résultats ou événements futurs, sur la base des opinions, hypothèses et estimations considérées comme raisonnables par la direction à la date à laquelle les déclarations sont faites. Bien que Charbone estime que les attentes exprimées dans les déclarations prospectives sont raisonnables, les déclarations prospectives comportent des risques et des incertitudes, et il ne faut pas se fier indûment aux déclarations prospectives, car des facteurs inconnus ou imprévisibles pourraient faire en sorte que les résultats réels soient sensiblement différents de ceux exprimés dans les déclarations prospectives. Des risques et des incertitudes liés aux activités de Charbone peuvent avoir une incidence sur les déclarations prospectives. Ces risques, incertitudes et hypothèses comprennent, sans s’y limiter, ceux décrits à la rubrique « Facteurs de risque » dans la déclaration de changement à l’inscription de la Société datée du 31 mars 2022, qui peut être consultée sur SEDAR à l’adresse www.sedar.com; ils pourraient faire en sorte que les événements ou les résultats réels diffèrent sensiblement de ceux prévus dans les déclarations prospectives.

Sauf si les lois sur les valeurs mobilières applicables l’exigent, Charbone ne s’engage pas à mettre à jour ni à réviser les déclarations prospectives.

Ni la Bourse de croissance TSX ni son fournisseur de services de réglementation (tel que ce terme est défini dans les politiques de la Bourse de croissance TSX) n’acceptent de responsabilité quant à la pertinence ou à l’exactitude du présent communiqué.

Pour contacter Corporation Charbone Hydrogène :

Copyright (c) 2025 TheNewswire – All rights reserved.

(TheNewswire)

Global private financial group headquartered in San Francisco advises on construction facility to support CHARBONE’s expansion of modular green hydrogen facilities in North America.

Brossard, Quebec TheNewswire – June 4, 2025 Charbone Hydrogen Corporation (TSXV: CH; OTCQB: CHHYF; FSE: K47) (the ‘Company’ or ‘CHARBONE’), rare publicly traded pure-play company focused on the production and distribution of green hydrogen in North America, is pleased to announce more details on the signing, announced previously on May 1st 2025, of a project finance facility of up to USD 50 million being provided by a private fund managed by True Green Capital Management LLC (‘TGC’). US Capital Global Securities LLC, the SEC-registered broker-dealer division of global private financial group US Capital Global has acted as lead advisor and facilitator.

Headquartered in Montreal, CHARBONE is developing modular production facilities targeting 99.999% purity (Grade 5.0 and higher) hydrogen, with all output pre-sold through tier-one offtake agreements.

‘ We’re proud to have served as lead advisor to both CHARBONE and TGC on this transaction ,’ said Charles Towle, CEO of US Capital Global Securities. ‘ CHARBONE is gaining strong momentum as demand grows for clean hydrogen solutions to decarbonize industrial users through their key sites in development across North America. We look forward to supporting the company’s continued growth. The transaction was led by Lisa Terk, Senior Vice President and a top CleanTech and Renewables banker at our global headquarters. ‘

‘ This financing marks an important milestone in executing our long-term growth strategy ,’ said Benoit Veilleux, CFO of CHARBONE. ‘ We are grateful to US Capital Global for their consistent support and expertise throughout this process—from structuring and investor engagement to the successful completion of legal documentation. ‘

Herv é Touati , Managing Director at TGC, added: ‘ We’re pleased to be financing CHARBONE and look forward to working together on this joint renewable clean energy initiative. We appreciate the diligence and insight of US Capital Global in bringing this opportunity to this stage. ‘

About Charbone Hydrogen Corporation

CHARBONE is an integrated green hydrogen company with strategic distribution capabilities of industrial gases across North America. While continuing to develop its modular green hydrogen production network, CHARBONE also leverages commercial partnerships to supply hydrogen, helium, and other industrial gases without the capital-intensive requirements of production facilities. This approach enhances revenue streams, reduces operational risks, and increases market flexibility. CHARBONE remains North America’s only publicly traded pure-play green hydrogen company, with shares listed on the TSX Venture Exchange (TSXV: CH), the OTC Markets (OTCQB: CHHYF), and the Frankfurt Stock Exchange (FSE: K47). For more information, visit www.charbone.com .

About True Green Capital Management

True Green Capital Management LLC (‘TGC’) is a specialized renewable energy infrastructure fund manager with a focus in distributed power generation in the US and Europe. Since 2011, TGC has financed and managed clean energy assets that generate stable, low-correlated returns. Headquartered in Westport, Connecticut, TGC also maintains an office in London. Learn more at www.truegreencapital.com .

About US Capital Global

Founded in 1998, US Capital Global offers a range of advanced financial solutions, including debt, equity, and investment products customized for middle-market enterprises and investors. The firm oversees direct investment funds while delivering comprehensive wealth management and investment banking services, encompassing M&A strategies and capital raising expertise. Among the notable entities within the consortium are US Capital Global Investment Management LLC, US Capital Global Wealth Management LLC, and US Capital Global Securities LLC, an SEC-registered broker-dealer and member of FINRA. To learn more, visit www.uscapital.com .

Forward-Looking Statements

This news release contains statements that are ‘forward-looking information’ as defined under Canadian securities laws (‘forward-looking statements’). These forward-looking statements are often identified by words such as ‘intends’, ‘anticipates’, ‘expects’, ‘believes’, ‘plans’, ‘likely’, or similar words. The forward-looking statements reflect management’s expectations, estimates, or projections concerning future results or events, based on the opinions, assumptions and estimates considered reasonable by management at the date the statements are made. Although Charbone believes that the expectations reflected in the forward-looking statements are reasonable, forward-looking statements involve risks and uncertainties, and undue reliance should not be placed on forward-looking statements, as unknown or unpredictable factors could cause actual results to be materially different from those reflected in the forward-looking statements. The forward-looking statements may be affected by risks and uncertainties in the business of Charbone. These risks, uncertainties and assumptions include, but are not limited to, those described under ‘Risk Factors’ in the Corporation’s Filing Statement dated March 31, 2022, which is available on SEDAR at www.sedar.com; they could cause actual events or results to differ materially from those projected in any forward-looking statements.

Except as required under applicable securities legislation, Charbone undertakes no obligation to publicly update or revise forward-looking information.

Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release .

Copyright (c) 2025 TheNewswire – All rights reserved.

Saga Metals Corp. (‘SAGA’ or the ‘Company’) (TSXV: SAGA) (OTCQB: SAGMF) (FSE: 20H) a North American exploration company focused on critical mineral discovery, is pleased to announce the appointment of Paul McGuigan, P. Geo., as its Qualified Person on the exploration and development of the Radar Ti-V-Fe Property (the ‘ Project ‘) in Labrador. Mr. McGuigan will advise on standards of practice for QAQC, structural mapping, drilling and deposit modelling.

Mr. McGuigan, a Professional Geoscientist, has 50 years of international experience in economic geology and mineral exploration management, spanning grassroots exploration to feasibility studies and mining operations. Early in his career, he was employed by IBM, the Geological Survey of Canada, Imperial Oil, Pechiney Ugine Kuhlmann, Esso Minerals Canada and Westmin Resources.

For the last 37 years, McGuigan has led Cambria Geological Inc., which has operated in North and South America, West Africa, the Middle East, the SW Pacific, and Europe. Clients have included private and publicly-listed companies, First Nations groups, and governments. He has been responsible for multiple feasibility-level projects involving due diligence standards, data validation, project management, mine rehabilitation, deposit modelling, and QAQC.

In decades of public service, McGuigan was a member of the Consulting Practice and Geoscience Committees of the Engineers and Geoscientists of BC, an executive/director of the BC Neurological Centre, and president/director of the BC Centre for Ability Foundation.

McGuigan’s geological expertise includes Fe-Ti-V-P in layered mafic intrusions, iron oxide-copper-gold (IOCG), volcanogenic massive sulphide, porphyry Cu-Mo-Au, epithermal and orogenic gold, and diamond deposits.

Regarding the Radar V-Ti-Fe project, McGuigan has served in several relevant roles on similar projects. In his early career, he researched gravity and magnetic separations, which led to novel heavy mineral sampling methods. For Esso Minerals, he supervised the structural mapping and mineral resource estimation of a complexly deformed, copper-bearing massive magnetite deposit, significantly improving the head grade and supporting the re-opening of the 8,000 tpd underground Granduc Mine in BC.

Later, McGuigan co-founded a commercial laboratory with Acme Analytical (now part of the Bureau Veritas group), conducting mineral separations and identifying and testing indicator minerals.

For a private Latin American group of companies, McGuigan served as the Qualified Person for testing V-Ti-Fe in Proterozoic layered mafic intrusions, including drilling, bulk sampling, pilot mill construction, and the construction of an on-site laboratory for mineral separations, XRF analysis, and QAQC. For that same client, McGuigan supervised the definition drilling and resource estimation of a heavy mineral sands deposit, with significant Ti-Fe in titanomagnetite.

In Canada, McGuigan has served as the Qualified Person and reviewed numerous Superior and Grenville Province V-T-Fe (P) deposits in layered mafic intrusions. In certain projects, he secured government grants for metallurgical and critical mineral technology.

Figure 1: Radar Property map, depicting aeromagnetic anomalies, oxide layering and the site of the 2025 drill program. The Property is well serviced by road access and is conveniently located near the town of Cartwright, Labrador. A compilation of historical aeromagnetic anomalies is shown. SAGA has demonstrated the reliability of the regional airborne magnetic surveys after ground-truthing and drilling in the 2024 and 2025 field programs.

Radar Ti-V-Fe Project Overview:

The Company’s 100%-owned Radar Property is located 10 km from the coastal city of Cartwright, Labrador, benefiting from tremendous infrastructure, including road access, deep-water port, airstrip and nearby hydro-electric power. The Radar Property comprises 24,175-hectares and entirely encloses the Dykes River intrusive complex mapped at 160km ² on surface.

The Dykes River intrusive complex is a recently recognized Mesoproterozoic layered mafic intrusion (Gower, 2017). It has gained attention due geological similarities to large AMCG-type intrusions and a very extensive titanium–vanadium–iron (Ti-V-Fe) rich layer.

Radar Ti-V-Fe Project 2025 Winter Drill Program Highlights:

• Analytical results have now been received on all 7 diamond drill holes from the 2025 winter program.
• Combined with petrographic analysis, these new assays further confirm that the primary economic mineral is vanadiferous titanomagnetite—favorable for simplified metallurgical processing.
• Titanomagnetite-rich zones average between 20% and 40% titanomagnetite, with localized massive layers exceeding 60%.
• Drilling has confirmed the presence of oxide layering and associated magnetic anomalies to vertical depths of up to 300 meters.
• Current drilling has tested just 1/40th of the identified 20 km strike extent of the oxide layering zone within the Dykes River Intrusion (refer to Figure 1 for map view) .

Marketing Services Agreement with Maximus Strategic Consulting Inc.

The Company also announces that it has entered into an online marketing agreement with Maximus Strategic Consulting Inc. (‘ Maximus ‘).  Pinnacle Digest and PinnacleDigest.com are business names of Maximus. Maximus has agreed to produce and distribute, through the email newsletter and YouTube channel of PinnacleDigest.com, a video highlighting the Company and its projects. Additionally, all the Company’s news releases during the term of the online marketing agreement will be featured in Pinnacle Digest’s weekly email newsletter.

The Company’s engagement of Maximus will run for a period of four months beginning on June 1, 2025, and the Company will pay Maximus a fee of C$150,000 (plus GST) paid in two instalments.  Maximus’ business address is 300 – 1550 5 St. SW Calgary, Alberta. T2R 1K3, email address is support@pinnacledigest.com . Maximus currently owns 300,000 common shares in the capital of the Company and 300,000 common share purchase warrants, each exercisable to acquire one common share at an exercise price of $0.50 per common share until May 23, 2027.

Qualified Person

Paul J. McGuigan, P. Geo. is an Independent Qualified Person as defined under National Instrument 43-101 and has reviewed and approved the technical information related to the Radar Ti-V-Fe Project disclosed in this news release.

About Saga Metals Corp.

Saga Metals Corp. is a North American mining company focused on the exploration and discovery of critical minerals that support the global transition to green energy. The Company’s flagship asset, the Double Mer Uranium Project, is located in Labrador, Canada, covering 25,600 hectares. This project features uranium radiometrics that highlight an 18km east-west trend, with a confirmed 14km section producing samples as high as 0.428% U ₃ O ₈ and uranium uranophane was identified in several areas of highest radiometric response (2024 Double Mer Technical Report).

In addition to its uranium focus, SAGA owns the Legacy Lithium Property in Quebec’s Eeyou Istchee James Bay region. This project, developed in partnership with Rio Tinto, has been expanded through the acquisition of the Amirault Lithium Project. Together, these properties cover 65,849 hectares and share significant geological continuity with other major players in the area, including Rio Tinto, Winsome Resources, Azimut Exploration, and Loyal Lithium.

SAGA also holds additional exploration assets in Labrador, where the company is focused on discovering titanium, vanadium, and iron ore. With a portfolio that spans key minerals crucial to the green energy transition, SAGA is strategically positioned to play an essential role in the clean energy future.

On Behalf of the Board of Directors

Mike Stier, Chief Executive Officer

For more information, contact:
Saga Metals Corp.
Investor Relations
Tel: +1 (778) 930-1321
Email: info@sagametals.com
www.sagametals.com

Neither the TSX Venture Exchange nor its Regulation Service Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release.

Cautionary Disclaimer

This news release contains forward-looking statements within the meaning of applicable securities laws that are not historical facts. Forward-looking statements are often identified by terms such as ‘will’, ‘may’, ‘should’, ‘anticipates’, ‘expects’, ‘believes’, and similar expressions or the negative of these words or other comparable terminology. All statements other than statements of historical fact, included in this release are forward-looking statements that involve risks and uncertainties. In particular, this news release contains forward-looking information pertaining to the exploration of the Company’s Radar Project. There can be no assurance that such statements will prove to be accurate and actual results and future events could differ materially from those anticipated in such statements. Important factors that could cause actual results to differ materially from the Company’s expectations include, but are not limited to, changes in the state of equity and debt markets, fluctuations in commodity prices, delays in obtaining required regulatory or governmental approvals, environmental risks, limitations on insurance coverage, risks and uncertainties involved in the mineral exploration and development industry, and the risks detailed in the Company’s continuous disclosure filings with securities regulations from time to time, available under its SEDAR+ profile at www.sedarplus.ca. The reader is cautioned that assumptions used in the preparation of any forward-looking information may prove to be incorrect. Events or circumstances may cause actual results to differ materially from those predicted, as a result of numerous known and unknown risks, uncertainties, and other factors, many of which are beyond the control of the Company. The reader is cautioned not to place undue reliance on any forward-looking information. Such information, although considered reasonable by management at the time of preparation, may prove to be incorrect and actual results may differ materially from those anticipated. Forward-looking statements contained in this news release are expressly qualified by this cautionary statement. The forward-looking statements contained in this news release are made as of the date of this news release and the Company will update or revise publicly any of the included forward-looking statements only as expressly required by applicable law.